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For participant with only 1 measurable lesion and prior radiotherapy, the lesion must be outside the field of prior radiotherapy or must have documented progression following radiation therapy. ) /Pg 7 0 R /K [9] >> endobj 61 0 obj << /Type /StructElem /S /P /P 273 0 R /E (QT interval by Fredericia \(QTcF\) =< 470 msec. ) /Pg 7 0 R /K [10] >> endobj 62 0 obj << /Type /StructElem /S /P /P 274 0 R /E (Participant has ECOG performance status of 0 or 1. ) /Pg 7 0 R /K [11] >> endobj 63 0 obj << /Type /StructElem /S /P /P 275 0 R /E (Disease Specific Criteria: Pancreatic Cancer ) /Pg 7 0 R /K [12] >> endobj 64 0 obj << /Type /StructElem /S /P /P 276 0 R /E (Participant has histologically or cytologically confirmed pancreatic adenocarcinoma. ) /Pg 7 0 R /K [13] >> endobj 65 0 obj << /Type /StructElem /S /P /P 277 0 R /E (Participant with pancreatic adenocarcinoma who has progressed, is intolerant, has refused, or for whom there is no standard approved therapies that impart significant clinical \(no limit to the number of prior treatment regimens\).) /Pg 7 0 R /K [14] >> endobj 66 0 obj << /Type /StructElem /S /P /P 278 0 R /E (Prior severe allergic reaction or intolerance to known ingredients of ASP2138 or other antibodies, including humanized or chimeric antibodies. ) /Pg 7 0 R /K [16] >> endobj 67 0 obj << /Type /StructElem /S /P /P 279 0 R /E (Received systemic immunosuppressive therapy, including systemic corticosteroids 14 days prior to first dose of study intervention.) /Pg 7 0 R /K [17] >> endobj 68 0 obj << /Type /StructElem /S /P /P 280 0 R /E (Complete gastric outlet syndrome or a partial gastric outlet syndrome with persistent/recurrent vomiting. ) /Pg 7 0 R /K [18] >> endobj 69 0 obj << /Type /StructElem /S /P /P 281 0 R /E (Gastric bleeding and/or untreated gastric ulcers that exclude the participant from participation.) /Pg 7 0 R /K [19] >> endobj 70 0 obj << /Type /StructElem /S /P /P 282 0 R /E (Symptomatic CNS metastases or participant has evidence of unstable CNS metastases even if asymptomatic. ) /Pg 7 0 R /K [20] >> endobj 71 0 obj << /Type /StructElem /S /P /P 283 0 R /E (Known HIV infection. ) /Pg 7 0 R /K [21] >> endobj 72 0 obj << /Type /StructElem /S /P /P 284 0 R /E (Participant is known to have active hepatitis B \(positive hepatitis B surface antigen [HBsAg]\) or hepatitis C infection. 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Continued) /Pg 8 0 R /K [1] >> endobj 83 0 obj << /Type /StructElem /S /P /P 292 0 R /E <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> /Pg 8 0 R /K [2] >> endobj 84 0 obj << /Type /StructElem /S /P /P 293 0 R /E (Received an CLDN18.2-targeted investigational agent \(e.g., zolbetuximab or chimeric antigen receptor CLDN18.2-specific T cells\) prior to first dose of study intervention administration is not eligible for dose escalation cohorts. However, a participant who has received an CLDN18.2-targeted investigational agent greater than 28 days or 5 half-lives \(whichever is longer\) prior to first dose study intervention administration is eligible for dose expansion cohorts only, except for participants who have experienced Grade >= 3 gastrointestinal \(GI\) toxicity after receiving an CLDN18.2-targeted investigational agent. ) /Pg 8 0 R /K [3] >> endobj 85 0 obj << /Type /StructElem /S /P /P 294 0 R /E (History or complication of interstitial lung disease.) /Pg 8 0 R /K [4] >> endobj 86 0 obj << /Type /StructElem /S /H1 /T (METASTATIC) /E (METASTATIC) /Alt () /Pg 8 0 R /K [0] >> endobj 87 0 obj << /Type /StructElem /S /P /P 295 0 R /E (Clinical Trial Name: MRTX1719 in Patients With Advanced Solid Tumors With Homozygous MTAP Deletion \(MIRATI 1719-001\)) /Pg 8 0 R /K [5] >> endobj 88 0 obj << /Type /StructElem /S /P /P 296 0 R /E (Study Design: The study is a Phase 1/2, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with) /Pg 8 0 R /K [6] >> endobj 89 0 obj << /Type /StructElem /S /P /P 296 0 R /E (advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.) /Pg 8 0 R /K [7] >> endobj 90 0 obj << /Type /StructElem /S /P /P 297 0 R /E (NCT#: NCT05245500) /Pg 8 0 R /K [8] >> endobj 91 0 obj << /Type /StructElem /S /P /P 298 0 R /E (Key Inclusion: ) /Pg 8 0 R /K [9] >> endobj 92 0 obj << /Type /StructElem /S /P /P 298 0 R /E <4B6579204578636C7573696F6E3A20B720> /Pg 8 0 R /K [17] >> endobj 93 0 obj << /Type /StructElem /S /P /P 299 0 R /E (Study PI: ) /Pg 8 0 R /K [24] >> endobj 94 0 obj << /Type /StructElem /S /P /P 299 0 R /E (Dr. Ben George) /Pg 8 0 R /K [25] >> endobj 95 0 obj << /Type /StructElem /S /P /P 300 0 R /E (Clinical Research) /Pg 8 0 R /K [26] >> endobj 96 0 obj << /Type /StructElem /S /P /P 300 0 R /E (Coordinator: ) /Pg 8 0 R /K [27] >> endobj 97 0 obj << /Type /StructElem /S /P /P 300 0 R /E (Nicholas Pucek) /Pg 8 0 R /K [28] >> endobj 98 0 obj << /Type /StructElem /S /P /P 300 0 R /E (Phone: 414-805-4639) /Pg 8 0 R /K [29] >> endobj 99 0 obj << /Type /StructElem /S /P /P 301 0 R /E (Histologically confirmed diagnosis of a solid tumor malignancy with homozygous deletion of the MTAP gene detected in tumor tissue or ctDNA) /Pg 8 0 R /K [10] >> endobj 100 0 obj << /Type /StructElem /S /P /P 302 0 R /E (Unresectable or metastatic disease ) /Pg 8 0 R /K [11] >> endobj 101 0 obj << /Type /StructElem /S /P /P 303 0 R /E (Patients must have received standard therapies appropriate for their tumor type and stage with disease progression on or after the most recent treatment ) /Pg 8 0 R /K [12] >> endobj 102 0 obj << /Type /StructElem /S /P /P 304 0 R /E (Phase 1 dose escalation, RECIST 1.1 measurable or evaluable disease ) /Pg 8 0 R /K [13] >> endobj 103 0 obj << /Type /StructElem /S /P /P 305 0 R /E <506861736520316220616E64205068617365203220636F686F7274732C2052454349535420312E31206D656173757261626C65206469736561736520B720> /Pg 8 0 R /K [14] >> endobj 104 0 obj << /Type /StructElem /S /P /P 306 0 R /E (Presence of a tumor lesion amenable to mandatory biopsy for pharmacodynamic evaluation at baseline and on-study unless Sponsor-confirmed as medically unsafe or infeasible ) /Pg 8 0 R /K [15] >> endobj 105 0 obj << /Type /StructElem /S /P /P 307 0 R /E (ECOG: 0 or 1) /Pg 8 0 R /K [16] >> endobj 106 0 obj << /Type /StructElem /S /P /P 308 0 R /E (Prior treatment with a PRMT5 or MAT2A inhibitor therapy. ) /Pg 8 0 R /K [18] >> endobj 107 0 obj << /Type /StructElem /S /P /P 309 0 R /E (Active brain metastases or carcinomatous meningitis. ) /Pg 8 0 R /K [19] >> endobj 108 0 obj << /Type /StructElem /S /P /P 310 0 R /E (History of significant hemoptysis or hemorrhage within 4 weeks of the first dose of study treatment. ) /Pg 8 0 R /K [20] >> endobj 109 0 obj << /Type /StructElem /S /P /P 311 0 R /E (Major surgery within 4 weeks of first dose of study treatment. ) /Pg 8 0 R /K [21] >> endobj 110 0 obj << /Type /StructElem /S /P /P 312 0 R /E (History of intestinal disease, inflammatory bowel disease, major gastric surgery, or other gastrointestinal conditions \(eg, uncontrolled nausea, vomiting, malabsorption syndrome\) likely to alter absorption of study treatment or result in inability to swallow oral medications) /Pg 8 0 R /K [22] >> endobj 111 0 obj << /Type /StructElem /S /P /P 313 0 R /E (Cardiac abnormalities) /Pg 8 0 R /K [23] >> endobj 112 0 obj << /Type /StructElem /S /H2 /T (NEW PATIENT COORDINATOR: 414-805-6849) /E (NEW PATIENT COORDINATOR: 414-805-6849) /Alt () /Pg 8 0 R >> endobj 113 0 obj << /Type /StructElem /S /P /E (Version: 02.04.25) /Alt () /Pg 8 0 R >> endobj 114 0 obj << /Type /StructElem /S /H1 /T (METASTATIC) /E (METASTATIC) /Alt () /Pg 9 0 R /K [0] >> endobj 115 0 obj << /Type /StructElem /S /P /P 314 0 R /E (Clinical Trial Name: A Study of NEOGENE Trial-NT-112 in HLA-C*08:02-Positive Adult Subjects with Unresectable, Advanced, And/ or Metastatic Solid Tumors Positive for the KRAS G12D Mutation \(NEOGENE Trial\)) /Pg 9 0 R /K [1] >> endobj 116 0 obj << /Type /StructElem /S /P /P 315 0 R /E (Study Design: This is a Phase 1, open-label, multicenter study to evaluate the safety and preliminary antitumor activity of NEOGENE Trial-NT-112 in HLA-) /Pg 9 0 R /K [2] >> endobj 117 0 obj << /Type /StructElem /S /P /P 315 0 R /E (C*08:02 subjects with unresectable, advanced, and/or metastatic NSCLC, colorectal adenocarcinoma, pancreatic adenocarcinoma, endometrial cancer, or any) /Pg 9 0 R /K [3] >> endobj 118 0 obj << /Type /StructElem /S /P /P 315 0 R /E (other solid tumor histology that is positive for the KRAS G21D mutation) /Pg 9 0 R /K [4] >> endobj 119 0 obj << /Type /StructElem /S /P /P 316 0 R /E (NCT#: NCT06218914) /Pg 9 0 R /K [5] >> endobj 120 0 obj << /Type /StructElem /S /P /P 317 0 R /E (Key Inclusion: ) /Pg 9 0 R /K [6] >> endobj 121 0 obj << /Type /StructElem /S /P /P 317 0 R /E (Key Exclusion: ) /Pg 9 0 R /K [12] >> endobj 122 0 obj << /Type /StructElem /S /P /P 318 0 R /E (Study PI: ) /Pg 9 0 R /K [22] >> endobj 123 0 obj << /Type /StructElem /S /P /P 318 0 R /E (Dr. Mandana Kamgar) /Pg 9 0 R /K [23] >> endobj 124 0 obj << /Type /StructElem /S /P /P 319 0 R /E (Clinical Research) /Pg 9 0 R /K [24] >> endobj 125 0 obj << /Type /StructElem /S /P /P 319 0 R /E (Coordinator: ) /Pg 9 0 R /K [25] >> endobj 126 0 obj << /Type /StructElem /S /P /P 319 0 R /E (Lauren Winkowski) /Pg 9 0 R /K [26] >> endobj 127 0 obj << /Type /StructElem /S /P /P 319 0 R /E (Phone: 414-805-8937) /Pg 9 0 R /K [27] >> endobj 128 0 obj << /Type /StructElem /S /P /P 320 0 R /E /Pg 9 0 R /K [7] >> endobj 129 0 obj << /Type /StructElem /S /P /P 321 0 R /E (Diagnosed with NSCLC, Colorectal adenocarcinoma, Pancreatic adenocarcinoma, Endometrial Cancer or any other solid tumor ) /Pg 9 0 R /K [8] >> endobj 130 0 obj << /Type /StructElem /S /P /P 322 0 R /E (Tumors must harbor a KRAS G12D variant mutation and subject must be HLA-C*08:02 positive ) /Pg 9 0 R /K [9] >> endobj 131 0 obj << /Type /StructElem /S /P /P 323 0 R /E (Subject has advanced solid cancer, defined as unresectable, advanced, and/or metastatic disease \(Stage III or IV\) after at least 1 line of approved systemic standard of care \(SOC\) treatment regimen and for which there are no available curative treatment options. ) /Pg 9 0 R /K [10] >> endobj 132 0 obj << /Type /StructElem /S /P /P 324 0 R /E <50726573656E6365206F66206174206C656173742031206D656173757261626C65206C6573696F6E20706572205245434953542076312E3120B7204561737465726E20436F6F7065726174697665204F6E636F6C6F67792047726F7570202845434F472920706572666F726D616E636520737461747573206F66203020746F2031206174207468652074696D65206F6620656E726F6C6C6D656E7420> /Pg 9 0 R /K [11] >> endobj 133 0 obj << /Type /StructElem /S /P /P 325 0 R /E (Any other primary malignancy within the 3 years prior to enrollment \(except for non-melanoma skin cancer, carcinoma in situ \(eg, cervix, bladder, breast\) or low-grade prostate cancer ) /Pg 9 0 R /K [13] >> endobj 134 0 obj << /Type /StructElem /S /P /P 326 0 R /E (Known, active primary central nervous system \(CNS\) malignancy ) /Pg 9 0 R /K [14] >> endobj 135 0 obj << /Type /StructElem /S /P /P 327 0 R /E (History of prior adoptive cell and gene therapy, allogeneic stem cell transplant or solid organ transplantation. ) /Pg 9 0 R /K [15] >> endobj 136 0 obj << /Type /StructElem /S /P /P 328 0 R /E (History of stroke or transient ischemic attack within the 12 months prior to enrollment.) /Pg 9 0 R /K [16] >> endobj 137 0 obj << /Type /StructElem /S /P /P 329 0 R /E (History of clinically significant cardiac disease within the 6 months prior to enrollment or heart failure at any time prior to enrollment. ) /Pg 9 0 R /K [17] >> endobj 138 0 obj << /Type /StructElem /S /P /P 330 0 R /E (Systemic therapy within at least 2 weeks or 3 half-lives, whichever is shorter, prior to enrollment. ) /Pg 9 0 R /K [18] >> endobj 139 0 obj << /Type /StructElem /S /P /P 331 0 R /E (Any form of primary immunodeficiency. ) /Pg 9 0 R /K [19] >> endobj 140 0 obj << /Type /StructElem /S /P /P 332 0 R /E (Active immune-mediated disease requiring systemic steroids or other immunosuppressive treatment \(except if related to prior checkpoint inhibitor therapy\) ) /Pg 9 0 R /K [20] >> endobj 141 0 obj << /Type /StructElem /S /P /P 333 0 R /E (Female of childbearing potential who is lactating or breast feeding at the time of enrollment) /Pg 9 0 R /K [21] >> endobj 142 0 obj << /Type /StructElem /S /H2 /T (NEW PATIENT COORDINATOR: 414-805-6849) /E (NEW PATIENT COORDINATOR: 414-805-6849) /Alt () /Pg 9 0 R >> endobj 143 0 obj << /Type /StructElem /S /P /E (Version: 02.04.25) /Alt () /Pg 9 0 R >> endobj 144 0 obj << /Type /StructElem /S /H1 /T (METASTATIC) /E (METASTATIC) /Alt () /Pg 10 0 R /K [0] >> endobj 145 0 obj << /Type /StructElem /S /P /P 334 0 R /E (Clinical Trial Name: Investigation of Profile-Related Evidence Determining Individualized Cancer Therapy for Patients \(IIT-GEORGE-I-PREDICT\)) /Pg 10 0 R /K [1] >> endobj 146 0 obj << /Type /StructElem /S /P /P 335 0 R /E (Study Design: The purpose of this study is to learn more about personalized cancer therapy, including response to treatment and its side effects. Personalized) /Pg 10 0 R /K [2] >> endobj 147 0 obj << /Type /StructElem /S /P /P 335 0 R /E (cancer therapy is the practice of making decisions about what kind of treatment patients should receive based on the characteristics of their tumor.) /Pg 10 0 R /K [3] >> endobj 148 0 obj << /Type /StructElem /S /P /P 336 0 R /E (NCT#: NCT05674825) /Pg 10 0 R /K [4] >> endobj 149 0 obj << /Type /StructElem /S /P /P 337 0 R /E (Key Inclusion: ) /Pg 10 0 R /K [5] >> endobj 150 0 obj << /Type /StructElem /S /P /P 338 0 R /E (Study PI: ) /Pg 10 0 R /K [28] >> endobj 151 0 obj << /Type /StructElem /S /P /P 338 0 R /E (Dr. Ben George) /Pg 10 0 R /K [29] >> endobj 152 0 obj << /Type /StructElem /S /P /P 339 0 R /E (Clinical Research) /Pg 10 0 R /K [30] >> endobj 153 0 obj << /Type /StructElem /S /P /P 339 0 R /E (Coordinator: ) /Pg 10 0 R /K [31] >> endobj 154 0 obj << /Type /StructElem /S /P /P 339 0 R /E (Paola Gonzalez) /Pg 10 0 R /K [32] >> endobj 155 0 obj << /Type /StructElem /S /P /P 339 0 R /E (Quevedo) /Pg 10 0 R /K [33] >> endobj 156 0 obj << /Type /StructElem /S /P /P 339 0 R /E (Phone: 414-805-2674) /Pg 10 0 R /K [34] >> endobj 157 0 obj << /Type /StructElem /S /P /P 340 0 R /E (Patient with aggressive solid malignancy must meet at least one of the following: ) /Pg 10 0 R /K [6] >> endobj 158 0 obj << /Type /StructElem /S /P /P 341 0 R /E /Pg 10 0 R /K [7] >> endobj 159 0 obj << /Type /StructElem /S /P /P 342 0 R /E (Refused standard therapies, OR ) /Pg 10 0 R /K [8] >> endobj 160 0 obj << /Type /StructElem /S /P /P 343 0 R /E (Cancer of unknown primary or a rare tumor \(i.e., fewer than 4 cases per 100,000 per year\) with no approved therapies. ) /Pg 10 0 R /K [9] >> endobj 161 0 obj << /Type /StructElem /S /P /P 344 0 R /E (Patient with aggressive solid malignancy irrespective of two-year mortality who, in the opinion of the investigator, has no treatment option expected to yield significant clinical benefit. ) /Pg 10 0 R /K [10] >> endobj 162 0 obj << /Type /StructElem /S /P /P 345 0 R /E (Patient must have at least one of the following for a diagnosis/disease status: ) /Pg 10 0 R /K [11] >> endobj 163 0 obj << /Type /StructElem /S /P /P 346 0 R /E (Unresectable disease, as determined by a disease-appropriate multidisciplinary tumor board. ) /Pg 10 0 R /K [12] >> endobj 164 0 obj << /Type /StructElem /S /P /P 347 0 R /E (Medically unfit for surgical resection but with an expected survival of > three months. ) /Pg 10 0 R /K [13] >> endobj 165 0 obj << /Type /StructElem /S /P /P 348 0 R /E (Localized disease and are eligible for neoadjuvant treatment. ) /Pg 10 0 R /K [14] >> endobj 166 0 obj << /Type /StructElem /S /P /P 349 0 R /E (Metastatic disease. ) /Pg 10 0 R /K [15] >> endobj 167 0 obj << /Type /StructElem /S /P /P 350 0 R /E (Disease where no conventional therapy leads to a survival benefit > six months in the respective cohort and line of therapy for which the patient is otherwise eligible. ) /Pg 10 0 R /K [16] >> endobj 168 0 obj << /Type /StructElem /S /P /P 351 0 R /E (Patient is either: ) /Pg 10 0 R /K [17] >> endobj 169 0 obj << /Type /StructElem /S /P /P 352 0 R /E <54726561746D656E74206E61EF766520666F72207468656972206E65776C7920646961676E6F736564206D616C69676E616E63792028666F7220656E726F6C6C6D656E7420746F2047726F7570732031206F722032292C206F7220> /Pg 10 0 R /K [18] >> endobj 170 0 obj << /Type /StructElem /S /P /P 353 0 R /E (Status post one or more systemic therapy regimens, whether matched or unmatched \(for enrollment to Group 3\). Note: There are no limitations on the number of prior local therapies. ) /Pg 10 0 R /K [19] >> endobj 171 0 obj << /Type /StructElem /S /P /P 354 0 R /E /Pg 10 0 R /K [20] >> endobj 172 0 obj << /Type /StructElem /S /P /P 355 0 R /E (ECOG:0-2 ) /Pg 10 0 R /K [21] >> endobj 173 0 obj << /Type /StructElem /S /P /P 356 0 R /E (New York Heart Association \(NYHA\) Functional Classification I-II ) /Pg 10 0 R /K [22] >> endobj 174 0 obj << /Type /StructElem /S /P /P 357 0 R /E (Adequate organ and marrow function as defined below: ) /Pg 10 0 R /K [23] >> endobj 175 0 obj << /Type /StructElem /S /P /P 358 0 R /E /Pg 10 0 R /K [24] >> endobj 176 0 obj << /Type /StructElem /S /P /P 359 0 R /E /Pg 10 0 R /K [25] >> endobj 177 0 obj << /Type /StructElem /S /P /P 360 0 R /E /Pg 10 0 R /K [26] >> endobj 178 0 obj << /Type /StructElem /S /P /P 361 0 R /E /Pg 10 0 R /K [27] >> endobj 179 0 obj << /Type /StructElem /S /H2 /T (NEW PATIENT COORDINATOR: 414-805-6849) /E (NEW PATIENT COORDINATOR: 414-805-6849) /Alt () /Pg 10 0 R >> endobj 180 0 obj << /Type /StructElem /S /P /E (Version: 02.04.25) /Alt () /Pg 10 0 R >> endobj 181 0 obj << /Type /StructElem /S /H1 /T (METASTATIC) /E (METASTATIC) /Alt () /Pg 11 0 R /K [0] >> endobj 182 0 obj << /Type /StructElem /S /P /P 362 0 R /E (Investigation of Profile-Related Evidence Determining Individualized Cancer Therapy for Patients \(IIT-GEORGE-I-PREDICT\) Continued) /Pg 11 0 R /K [1] >> endobj 183 0 obj << /Type /StructElem /S /P /P 363 0 R /E (Key Exclusion: ) /Pg 11 0 R /K [5] >> endobj 184 0 obj << /Type /StructElem /S /P /P 364 0 R /E (At the time of treatment, patient should be off other anti-tumor agents for at least five half-lives of the agent or two weeks from the last day of treatment, whichever is shorter to enroll in Group 3. Patient must not have been treated with anti-tumor agents to enroll in Group 1 or Group 2. Patient must be off prior antibody therapy for at least three half-lives before starting treatment. ) /Pg 11 0 R /K [2] >> endobj 185 0 obj << /Type /StructElem /S /P /P 365 0 R /E (If actionable or appropriate molecular profiling has not already been performed, patient must have or provide evaluable tissue and/or blood for molecular profiling. This could be obtained during the standard of care tumor diagnosis or tumor staging evaluation. 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+~:3 wٹǭ3},We1ppS@*rK?l㢵FoIl<4 t{^Orsx?Л:v?7y?#[gr ގ/ `DIHodF[h0)!a0#N#f:LdiXI F6, rEG.!|(H_`} CKȐK L_ NaҗaT6:b p: ;p`v:R A'QR(D tU㨆c$8jPM#8PCaj3F(`4X1tPOGрz^x1>@G0t#&:IOGa"F3&aLaj th1-tXV0mtN0!CP0> LCi!f!@bLp fQE#9\ kx'!D1_ûX9t Ip)t0`1_ZzK5؍..2\J`9.w\%@7+U覷[m\M zjpp%\Eq=VW~~DǍ^ ބz \Oa-~La_p3Vӫ9~JHV}n ڇXwgwfڃp3nB{K^4xnWp/nWp+i7.څ_c4_^o+z=#^p~EN(oh'6glôaځ=@<i£<xFz[6li;kph;^چ?)چxE-z-ڌ#x6SCoxQK&|1Aڄ8HsOpF|Cpz%> S/aڈopzw Ƨԋo(QQ3zGīGB:$ FINS IIO $ OJrb 3M/lweemmu. Tg^d3Xw.~~}@Pň'`}I0j!y̨]Qָ [aOjaPlѐqbE} #^Q* %3YꪱL˪CS[Q:̭6ҷfe]?䨮m 8N[}UK;B߯ޖMSJadTzr32DCfQL3nPrcÕS檷BĀ9i,e{,c72NiJ,.+i a"놌2 +] uPA|hw*,ؑȚ}dQ:oϥP~gt`^ySg{f?[19;rUW`Fs%5MЭWxį?_|l/ey 'g C[sF{z#wj^!aPV+N#ťss--w*,+osң-T/e֡jd Vj(TW jTX%,pTW:˂J몫m+"7:dΒ /f ڇIECJ3g(S;4_4q&_a~Quj]eN}"0PYRX/dgY23馴crRA,x<Fk$qefQK2v ?l S"f:)sElV9jeEh\-m;,b5z92{aâع`3q5m(,$gY9n;X{ \<ѐRD],kVζ@orLRh&%{d^f4D0F 08ܬS? gm 6k,N8mfXF\5BZ=!Rc[d] svc p]Hq:z:xuFl>|7ᰪ͞"F:9p²ʭ6:<Q&r7py\}HE|9 $u(gse*tHlt:| Ԝ M+lja-;!Y-к#&nJeYhc &/ nJ4dY| ՏQqL9_w@)b I\g;,\1& NGdk?cq-{BJnS9FEy$_j"FgMӱ|=3mqD^v"FL:cb4)V[F@#`]ȲW;G9kWeeYl6#& FB}3*^1 J-B}Z7S)FfSgTS$u7KUAŎ${y֓QYԻNԊT15g\5vNLKK$bTey0yO[ 0GO]BPlXUv:rϮH,Օi0oj6VހNb T,n5Inm61%*r{D"9j 6^LhiYJGgˮ,c$_$݊}[.O7[Uwi_Z5}'QI OUnzTNMC$ԥ&KFPij}t0ب^jI"WhWkNZ=kE~:k=#dC,KG Z1SYUWFq@&ب5r$I䞼XkS:O^d]g/'Ǟ8lj-cja'4pr{ZjU~hp:z4Zٚ^[3eF` t6 LalM[`x4RUԅ=Q0hУq4Ǡ 4}BfT䁀}qQg@:s QZFF/Ԁx=O(b?Ó Hddd)L&zĨD'jᚩg:#Ɉ&jPQu8.-`|R{ZHPQ VT.bW/ÏAěm endstream endobj 714 0 obj << /Length 5315 /Length1 8468 /Filter /FlateDecode >> stream xX |SUߗI۴MӦk{$ MSXP PH K\P3GGQquft :"".h,8}r޹{Yo =СeJY< !í_$u.u t@j+o Hu_<7n 0@_o/Z9L@ '{ ` ǫ u-^qFgthPݐQ_}`ҒN1OqJ+X^W}

+~:3 wٹǭ3},We1ppS@*rK?l㢵FoIl<4 t{^Orsx?Л:v?7y?#[gr ގ/ `DIHodF[h0)!a0#N#f:LdiXI F6, rEG.!|(H_`} CKȐK L_ NaҗaT6:b p: ;p`v:R A'QR(D tU㨆c$8jPM#8PCaj3F(`4X1tPOGрz^x1>@G0t#&:IOGa"F3&aLaj th1-tXV0mtN0!CP0> LCi!f!@bLp fQE#9\ kx'!D1_ûX9t Ip)t0`1_ZzK5؍..2\J`9.w\%@7+U覷[m\M zjpp%\Eq=VW~~DǍ^ ބz \Oa-~La_p3Vӫ9~JHV}n ڇXwgwfڃp3nB{K^4xnWp/nWp+i7.څ_c4_^o+z=#^p~EN(oh'6glôaځ=@<i£<xFz[6li;kph;^چ?)چxE-z-ڌ#x6SCoxQK&|1Aڄ8HsOpF|Cpz%> S/aڈopzw Ƨԋo(QQ3zGīGB:$ FINS IIO $ OJrb 3M/lweemmu. Tg^d3Xw.~~}@Pň'`}I0j!y̨]Qָ [aOjaPlѐqbE} #^Q* %3YꪱL˪CS[Q:̭6ҷfe]?䨮m 8N[}UK;B߯ޖMSJadTzr32DCfQL3nPrcÕS檷BĀ9i,e{,c72NiJ,.+i a"놌2 +] uPA|hw*,ؑȚ}dQ:oϥP~gt`^ySg{f?[19;rUW`Fs%5MЭWxį?_|l/ey 'g C[sF{z#wj^!aPV+N#ťss--w*,+osң-T/e֡jd Vj(TW jTX%,pTW:˂J몫m+"7:dΒ /f ڇIECJ3g(S;4_4q&_a~Quj]eN}"0PYRX/dgY23馴crRA,x<Fk$qefQK2v ?l S"f:)sElV9jeEh\-m;,b5z92{aâع`3q5m(,$gY9n;X{ \<ѐRD],kVζ@orLRh&%{d^f4D0F 08ܬS? gm 6k,N8mfXF\5BZ=!Rc[d] svc p]Hq:z:xuFl>|7ᰪ͞"F:9p²ʭ6:<Q&r7py\}HE|9 $u(gse*tHlt:| Ԝ M+lja-;!Y-к#&nJeYhc &/ nJ4dY| ՏQqL9_w@)b I\g;,\1& NGdk?cq-{BJnS9FEy$_j"FgMӱ|=3mqD^v"FL:cb4)V[F@#`]ȲW;G9kWeeYl6#& FB}3*^1 J-B}Z7S)FfSgTS$u7KUAŎ${y֓QYԻNԊT15g\5vNLKK$bTey0yO[ 0GO]BPlXUv:rϮH,Օi0oj6VހNb T,n5Inm61%*r{D"9j 6^LhiYJGgˮ,c$_$݊}[.O7[Uwi_Z5}'QI OUnzTNMC$ԥ&KFPij}t0ب^jI"WhWkNZ=kE~:k=#dC,KG Z1SYUWFq@&ب5r$I䞼XkS:O^d]g/'Ǟ8lj-cja'4pr{ZjU~hp:z4Zٚ^[3eF` t6 LalM[`x4RUԅ=Q0hУq4Ǡ 4}BfT䁀}qQg@:s QZFF/Ԁx=O(b?Ó Hddd)L&zĨD'jᚩg:#Ɉ&jPQu8.-`|R{ZHPQ VT.bW/ÏAěm endstream endobj 715 0 obj << /Length 5315 /Length1 8468 /Filter /FlateDecode >> stream xX |SUߗI۴MӦk{$ MSXP PH K\P3GGQquft :"".h,8}r޹{Yo =СeJY< !í_$u.u t@j+o Hu_<7n 0@_o/Z9L@ '{ ` ǫ u-^qFgthPݐQ_}`ҒN1OqJ+X^W}

+~:3 wٹǭ3},We1ppS@*rK?l㢵FoIl<4 t{^Orsx?Л:v?7y?#[gr ގ/ `DIHodF[h0)!a0#N#f:LdiXI F6, rEG.!|(H_`} CKȐK L_ NaҗaT6:b p: ;p`v:R A'QR(D tU㨆c$8jPM#8PCaj3F(`4X1tPOGрz^x1>@G0t#&:IOGa"F3&aLaj th1-tXV0mtN0!CP0> LCi!f!@bLp fQE#9\ kx'!D1_ûX9t Ip)t0`1_ZzK5؍..2\J`9.w\%@7+U覷[m\M zjpp%\Eq=VW~~DǍ^ ބz \Oa-~La_p3Vӫ9~JHV}n ڇXwgwfڃp3nB{K^4xnWp/nWp+i7.څ_c4_^o+z=#^p~EN(oh'6glôaځ=@<i£<xFz[6li;kph;^چ?)چxE-z-ڌ#x6SCoxQK&|1Aڄ8HsOpF|Cpz%> S/aڈopzw Ƨԋo(QQ3zGīGB:$ FINS IIO $ OJrb 3M/lweemmu. Tg^d3Xw.~~}@Pň'`}I0j!y̨]Qָ [aOjaPlѐqbE} #^Q* %3YꪱL˪CS[Q:̭6ҷfe]?䨮m 8N[}UK;B߯ޖMSJadTzr32DCfQL3nPrcÕS檷BĀ9i,e{,c72NiJ,.+i a"놌2 +] uPA|hw*,ؑȚ}dQ:oϥP~gt`^ySg{f?[19;rUW`Fs%5MЭWxį?_|l/ey 'g C[sF{z#wj^!aPV+N#ťss--w*,+osң-T/e֡jd Vj(TW jTX%,pTW:˂J몫m+"7:dΒ /f ڇIECJ3g(S;4_4q&_a~Quj]eN}"0PYRX/dgY23馴crRA,x<Fk$qefQK2v ?l S"f:)sElV9jeEh\-m;,b5z92{aâع`3q5m(,$gY9n;X{ \<ѐRD],kVζ@orLRh&%{d^f4D0F 08ܬS? gm 6k,N8mfXF\5BZ=!Rc[d] svc p]Hq:z:xuFl>|7ᰪ͞"F:9p²ʭ6:<Q&r7py\}HE|9 $u(gse*tHlt:| Ԝ M+lja-;!Y-к#&nJeYhc &/ nJ4dY| ՏQqL9_w@)b I\g;,\1& NGdk?cq-{BJnS9FEy$_j"FgMӱ|=3mqD^v"FL:cb4)V[F@#`]ȲW;G9kWeeYl6#& FB}3*^1 J-B}Z7S)FfSgTS$u7KUAŎ${y֓QYԻNԊT15g\5vNLKK$bTey0yO[ 0GO]BPlXUv:rϮH,Օi0oj6VހNb T,n5Inm61%*r{D"9j 6^LhiYJGgˮ,c$_$݊}[.O7[Uwi_Z5}'QI OUnzTNMC$ԥ&KFPij}t0ب^jI"WhWkNZ=kE~:k=#dC,KG Z1SYUWFq@&ب5r$I䞼XkS:O^d]g/'Ǟ8lj-cja'4pr{ZjU~hp:z4Zٚ^[3eF` t6 LalM[`x4RUԅ=Q0hУq4Ǡ 4}BfT䁀}qQg@:s QZFF/Ԁx=O(b?Ó Hddd)L&zĨD'jᚩg:#Ɉ&jPQu8.-`|R{ZHPQ VT.bW/ÏAěm endstream endobj 716 0 obj << /Length 5315 /Length1 8468 /Filter /FlateDecode >> stream xX |SUߗI۴MӦk{$ MSXP PH K\P3GGQquft :"".h,8}r޹{Yo =СeJY< !í_$u.u t@j+o Hu_<7n 0@_o/Z9L@ '{ ` ǫ u-^qFgthPݐQ_}`ҒN1OqJ+X^W}

+~:3 wٹǭ3},We1ppS@*rK?l㢵FoIl<4 t{^Orsx?Л:v?7y?#[gr ގ/ `DIHodF[h0)!a0#N#f:LdiXI F6, rEG.!|(H_`} CKȐK L_ NaҗaT6:b p: ;p`v:R A'QR(D tU㨆c$8jPM#8PCaj3F(`4X1tPOGрz^x1>@G0t#&:IOGa"F3&aLaj th1-tXV0mtN0!CP0> LCi!f!@bLp fQE#9\ kx'!D1_ûX9t Ip)t0`1_ZzK5؍..2\J`9.w\%@7+U覷[m\M zjpp%\Eq=VW~~DǍ^ ބz \Oa-~La_p3Vӫ9~JHV}n ڇXwgwfڃp3nB{K^4xnWp/nWp+i7.څ_c4_^o+z=#^p~EN(oh'6glôaځ=@<i£<xFz[6li;kph;^چ?)چxE-z-ڌ#x6SCoxQK&|1Aڄ8HsOpF|Cpz%> S/aڈopzw Ƨԋo(QQ3zGīGB:$ FINS IIO $ OJrb 3M/lweemmu. Tg^d3Xw.~~}@Pň'`}I0j!y̨]Qָ [aOjaPlѐqbE} #^Q* %3YꪱL˪CS[Q:̭6ҷfe]?䨮m 8N[}UK;B߯ޖMSJadTzr32DCfQL3nPrcÕS檷BĀ9i,e{,c72NiJ,.+i a"놌2 +] uPA|hw*,ؑȚ}dQ:oϥP~gt`^ySg{f?[19;rUW`Fs%5MЭWxį?_|l/ey 'g C[sF{z#wj^!aPV+N#ťss--w*,+osң-T/e֡jd Vj(TW jTX%,pTW:˂J몫m+"7:dΒ /f ڇIECJ3g(S;4_4q&_a~Quj]eN}"0PYRX/dgY23馴crRA,x<Fk$qefQK2v ?l S"f:)sElV9jeEh\-m;,b5z92{aâع`3q5m(,$gY9n;X{ \<ѐRD],kVζ@orLRh&%{d^f4D0F 08ܬS? gm 6k,N8mfXF\5BZ=!Rc[d] svc p]Hq:z:xuFl>|7ᰪ͞"F:9p²ʭ6:<Q&r7py\}HE|9 $u(gse*tHlt:| Ԝ M+lja-;!Y-к#&nJeYhc &/ nJ4dY| ՏQqL9_w@)b I\g;,\1& NGdk?cq-{BJnS9FEy$_j"FgMӱ|=3mqD^v"FL:cb4)V[F@#`]ȲW;G9kWeeYl6#& FB}3*^1 J-B}Z7S)FfSgTS$u7KUAŎ${y֓QYԻNԊT15g\5vNLKK$bTey0yO[ 0GO]BPlXUv:rϮH,Օi0oj6VހNb T,n5Inm61%*r{D"9j 6^LhiYJGgˮ,c$_$݊}[.O7[Uwi_Z5}'QI OUnzTNMC$ԥ&KFPij}t0ب^jI"WhWkNZ=kE~:k=#dC,KG Z1SYUWFq@&ب5r$I䞼XkS:O^d]g/'Ǟ8lj-cja'4pr{ZjU~hp:z4Zٚ^[3eF` t6 LalM[`x4RUԅ=Q0hУq4Ǡ 4}BfT䁀}qQg@:s QZFF/Ԁx=O(b?Ó Hddd)L&zĨD'jᚩg:#Ɉ&jPQu8.-`|R{ZHPQ VT.bW/ÏAěm endstream endobj 717 0 obj << /Length 5045 /Length1 7912 /Filter /FlateDecode >> stream xX |SUI۔&iӅ[^.aK-MXĄ.uA!UTFy㩊SPqC, *cEEEԑ~ݛ˛~_{η;ߖHE h\W$-/<*_]?'* 7B-R&$@{qkӜ~ˀ5M0A3sEo[H|nHXF777Z69 ?VWqƃ+愯he]34;vy R' 6Lol}ͫ+! LH"B*4?d"^`Ik`uy1 "g:̙ ٠ |ΡnR{vւ!BL2N"mI xJJ1y΂|Y*1x ݳw,sԯY#tLfI`ȣڭbLOYREJ*qZm籎ŒLc.S%3<ǔAlȳf]ٷT^Q_2ɺ|÷W!|0iP+[Ut~Csg @lFڮ 1,ÞnLPd\a˜)< gμ},󼆸i_<\X:'fLljz(iL]o߮ BBRbBhKbjᴋj*e{lZeaZ5.D&iEBFKIO3`@IIAGzvX 2L.$"kFg3ژA[1Ǫ0b޴߱v.pQ[yȔR5A<%]ǴF3\TL+&hI|(vO0]\_7tx'`c<5RAʐk' B%sEd[`yWJkrc2 2IOoWsZ*)gU*db׊]BPs fQwI#!)hKűd\zԒ #2AIf[[{{7̎)dZ `zD:$$HF2f):~3RJ?âC+,l?4 :#~B#2uLȢDdq?q :30Ct 2$:ADǠp0:?0:p P:FG0:ta.:\0#G.FIÃB::hC8 0a FA:qCߡcggxq69((s Gq.0\q.Ga"} L1 5&JTW$ը}A%}ZT>LdڇQCpjiB@Χ} sLJB瘎: a*}h/˜Na^B N{шS\&͘Ab&-O1 ԍٸ1Mԭ>O0 Z1,ڃM{sh.\a.hq.7JW*,p5Gч.ݸVmv:,ݸWnܠq5}Ÿv&:\6zKq {X=܂.]ܪvb%.c)m.܎evB;q'n N ځvmcmǟpmƃc C:|[x[3mx[x m .ŃԅuP Oaôx)i{h=i=ZtxԉC:=>szG?1|Ip_ѳ_:,~774~z'=g@8HO{/ZN\q^`bs|xK>x1Eg5SXv9G 6tc2H8 G쟝aOOY-RI&cB|A`p, [x/Jbyҡ<(+Vɓc\<ɑxT%$npX Q8s( |XuPV,}tUux_PE.8(78&n AǔsTO'-E"Y9|`VUmXaqwî*G1Q<sƙv M7|ohQ 3y%tҩ.Z=,V`GrO5&nt:}/YCpg3}!c;R.nk]C)ei')i$pw]E >n!02õ)ӂ!AiO rCXu:`pkyN.  5KZtEO7KL5iQ? 򄅔2'7˛Dnos(e!FQj@U4G{A6ZB_^Ȳt-K]sVʲ8^D+H(dQ"fs.a/W%jOrvE.ekOc5ɍ>d;,J^IDn)JZ촠^o9j\2̚D7&Yên,kӋn۪ѽS9U.4ʦ^}Fio܏X4&Oޛ`'PMEH [ A[%9T3>(v[<$acn*LpX+o0"Y1giߐYYZ_*IH(k^+mwq(զh7_;ku'Q*n[]\%B~*}!f-\ -COEwRwLkZI$Wh"ܮi-un.ig!^j1/tkW9^HL/E~IYNѧӊGmwݟON .8ZHzxCcO#T7ܫ:xxv -u:v(lIU- ҒS|Rc0[R\/^+hX m$mT|J0z/ЦStdq^C}Y芼Px{Pit>:9ě5yf!EW>5m`@"fĎ6W;Y[GWr!y.rRf0Qjg5+" ^6GB4m\UrhXSk_d endstream endobj 718 0 obj << /Length 5315 /Length1 8468 /Filter /FlateDecode >> stream xX |SUߗI۴MӦk{$ MSXP PH K\P3GGQquft :"".h,8}r޹{Yo =СeJY< !í_$u.u t@j+o Hu_<7n 0@_o/Z9L@ '{ ` ǫ u-^qFgthPݐQ_}`ҒN1OqJ+X^W}

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