Andreas Beyer Lab
Andreas M. Beyer, PhD
Curriculum Vitae (PDF)
Twitter: @BeyerLab
abeyer@mcw.edu
is a Professor in the Departments of Medicine and Physiology at the 91ɫƵ and the co-director of the Basic and translational research program in Cardio-Oncology.
During his training in Genetics and Physiology, he has gained detailed expertise in generating and evaluating novel approaches in genetics, molecular biology and physiology. In his time spent in the lab he performs experimental troubleshooting involving video microscopy, fluorescent microvascular imaging, generation of genetic rodent models, physiological evaluation of in vivo vascular function and blood pressure. With the support of this research group and important local and national collaborators, the Beyer lab is using live human tissues to address important questions in vascular biology that will lead to clinically relevant findings and drive further exploration of mechanism in rodent models. His lab hopes that clinically relevant data from human tissues will enable a detailed mechanistic understanding of disease that can then be used to develop novel therapeutics and translate both diagnostics and therapies themselves to the clinic.
Lab Projects
Current Members
Laura Norwood Toro
Research Scientist I
lnorwood@mcw.edu
Laura Norwood Toro is a Research Scientist I in the Andreas Beyer Lab. Her primary responsibility is to explore the effect of chemotherapy on cardiovascular outcomes in coronary circulation and vascular endothelium. One focus of her studies is to investigate the functions of telomerase in the nucleus versus the mitochondria. Her background is in cell biology and molecular biology.
Bill Hughes, PhD
Postdoctoral Fellow
whughes@mcw.edu
Bill Hughes is a postdoctoral fellow in the Beyer/Gutterman Lab. Prior to starting at 91ɫƵ he received his PhD from the University of Iowa. His research interests are human integrative cardiovascular physiology and vascular biology in health, aging, and chronic disease. In collaboration with Dr. Beyer and Dr. Gutterman, he is studying the cross-talk between autophagy, a basic cellular recycling process, and telomerase within the context of microvascular function in coronary artery disease (CAD). Flow-mediated dilation is predominately mediated by nitric oxide (NO) in healthy populations, but this mediator switches to hydrogen peroxide (H2O2) with CAD. Autophagy has recently been demonstrated to be sensitive to shear stress, and preliminary data from our lab indicates that inhibition of autophagy switches the mediator of FMD from NO to H2O2 in non-CAD vessels, while activation of autophagy in CAD vessels recapitulates a healthy phenotype (NO-mediated). Additionally, our lab has also demonstrated that upregulation of telomerase reduces mitochondrial release of H2O2 in vessels with CAD, restoring NO-mediated FMD. In this context, it is possible that there is significant crosstalk between pathways, with telomerase upstream of autophagy. Collectively, as numerous chronic diseases modulate both telomerase activity and autophagy it remains unknown how these two processes are inherently linked in the context of CAD.
Shelby Hader
Research Technologist II
shader@mcw.edu
Shelby Hader is a Research Technologist II in the Beyer/Gutterman Lab. Prior to starting at 91ɫƵ she received her BA from the Lawrence University. Her primary goal is to analyze the vascular reactivity of human coronary arterioles and adipose micro vessels within different healthy and diseased patients. Some of her projects include: the cardiotoxicity of chemotherapy upon the microvasculature along with measuring the differences between fission and fusion of mitochondria in human arterioles. Additionally, Shelby provides research support for multiple projects in the lab via imaging, dissection of discarded tissue, and rat/mice colony maintenance.
Steve Hammond, PhD
Postdoctoral Fellow
Steve Hammond is a postdoctoral fellow in the Beyer lab. Prior to his start at 91ɫƵ, he earned his doctorate from Kansas State University where he investigated the adverse cardiovascular consequences of 5-fluorouracil chemotherapy and modalities to alleviate their occurrence. Steve is most interested in better understanding the mitochondrial contributions to cardiovascular function in health in disease. He is currently studying the role of mitochondrial signaling in the development of anticancer therapy induced microvascular dysfunction. Specifically, his primary projects aim to elucidate the role of tumor derived circulating factors and alterations in mitochondrial calcium signaling in the development of microvascular pathology during anti-cancer treatment.
Erin Birch
Research Technologist I
ebirch@mcw.edu
Erin Birch is a research technologist in Dr. Beyer and Dr. Zhang’s labs. Erin has experience researching autoimmune diseases, chronic kidney disease, and cardiovascular disease. She is working with Dr. Beyer’s lab to provide support with several projects. Erin also contributes to the analysis of microvascular function in patients with coronary artery disease, COVID-19, and healthy patients. In her free time, Erin enjoys traveling and adventuring in the Rocky Mountains.
Lukas Brandt
Research Assistant
lbrandt@mcw.edu
Lukas Brandt is a graduate student in Dr. Beyer's lab. Prior to starting at 91ɫƵ's physiology program, he received his bachelor's degree from the University of Applied Science Bingen, Germany with a major in biotechnology. He received additional training in a Molecular Biology master program at the Goethe University Frankfurt, Germany before pursuing his education in physiology at 91ɫƵ. His research interests are whole organ physiology with a focus on cardiovascular pathology in response to clinical used anti-cancer therapy. Lukas aims to utilize rodent models to investigate physiological and molecular changes that lead to cardiovascular disease.
Cristhian Gutierrez Huerta
Research Assistant
cgutierrez@mcw.edu
Cristhian Gutierrez Huerta is a graduate MSTP student in the Beyer/Gutterman Lab. He graduated with a BS in Applied Mathematics and Biological Sciences from the University of California, Merced in 2018. He then completed a 2-yr post-baccalaureate research fellowship at the National Heart, Lung, and Blood Institute. In the Beyer/Gutterman group, he will begin work on identifying the role of mitochondrial fission/fusion on microvascular endothelial function and its relationship to coronary artery disease progression.
Karen Clark, PhD
Postdoctoral Fellow
kaclark@mcw.edu
Karen Clark is a postdoctoral fellow working with Drs Beyer and Kriegel to investigate biological factors that lead to disparate chemotherapy treatment outcomes in breast cancer patients of color compared to Caucasian women. She is also studying the role of mitofusin 1 in the vascular endothelium and whether overexpression is a protective factor against certain stressors. Prior to joining the team, she earned her PhD in Genetics at the University of Iowa, investigating the genetic basis of susceptibility to complex diseases in a rat model of Metabolic Syndrome. Her research interests include Precision Medicine, cancer biology, and metabolism.
Alumni/Former Trainees
- Daniela Didier
- Johnathan Ebben
- Alena Hanson
- Joe Hockenberry
- Andrew D. Kadlec, PhD
- Minhi Kang
- Todd Le
- Jasmine Linn
- Micaela Young
Recent Publications
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(Abe JI, Allen BG, Beyer AM, Lewandowski D, Mapuskar KA, Subramanian V, Tamplin MR, Grumbach IM.) Arterioscler Thromb Vasc Biol. 2024 Dec;44(12):2407-2415 PMID: 39445428 SCOPUS ID: 2-s2.0-85207953419 10/24/2024
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(Hasan P, Berezhnaya E, Rodríguez-Prados M, Weaver D, Bekeova C, Cartes-Saavedra B, Birch E, Beyer AM, Santos JH, Seifert EL, Elrod JW, Hajnóczky G.) Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2402491121 PMID: 39163336 PMCID: PMC11363308 SCOPUS ID: 2-s2.0-85201851900 08/20/2024
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(Aljadah M, Khan N, Beyer AM, Chen Y, Blanker A, Widlansky ME.) JACC Adv. 2024 Aug;3(8):101070 PMID: 39055276 PMCID: PMC11269277 07/26/2024
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(SenthilKumar G, Hammond ST, Zirgibel Z, Cohen KE, Beyer AM, Freed JK.) J Mol Cell Cardiol. 2024 Aug;193:67-77 PMID: 38848808 PMCID: PMC11260236 SCOPUS ID: 2-s2.0-85195369481 06/08/2024
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(Elgazzaz M, Lakkappa N, Berdasco C, Mohan UP, Nuzzo A, Restivo L, Martinez A, Scarborough A, Guidry JJ, Sriramula S, Xu J, Daoud H, Mendiola Plá MA, Bowles DE, Beyer AM, Mauvais-Jarvis F, Yue X, Filipeanu CM, Lazartigues E.) medRxiv. 2024 May 25 PMID: 38826318 PMCID: PMC11142264 06/03/2024
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(Bikomeye JC, Awoyinka I, Kwarteng JL, Beyer AM, Rine S, Beyer KMM.) Heart Lung Circ. 2024 May;33(5):576-604 PMID: 38184426 PMCID: PMC11144115 SCOPUS ID: 2-s2.0-85181809389 01/07/2024
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(Jahan J, Joshi S, Oca IM, Toelle A, Lopez-Yang C, Chacon CV, Beyer AM, Garcia CA, Jarajapu YP.) Biochem Pharmacol. 2024 Apr;222:116109 PMID: 38458330 PMCID: PMC11007670 SCOPUS ID: 2-s2.0-85187326117 03/09/2024
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(Asulin M, Gorodetzer N, Fridman R, Shelly Ben-Shushan R, Cohen Z, Beyer AM, Chuyun D, Gutterman DD, Szuchman-Sapir A.) Biochem Biophys Res Commun. 2024 Mar 12;700:149585 PMID: 38290177 SCOPUS ID: 2-s2.0-85183513377 01/30/2024
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(Aljadah M, Khan N, Beyer AM, Chen Y, Blanker A, Widlansky ME.) JACC: Advances. August 2024;3(8) SCOPUS ID: 2-s2.0-85197318304 08/01/2024
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(Mohammed M, Ogunlade B, Elgazzaz M, Berdasco C, Lakkappa N, Ghita I, Guidry JJ, Sriramula S, Xu J, Restivo L, Mendiola Plá MA, Bowles DE, Beyer AM, Yue X, Lazartigues E, Filipeanu CM.) Cardiovasc Res. 2023 Sep 05;119(11):2130-2141 PMID: 37161607 PMCID: PMC10478751 SCOPUS ID: 2-s2.0-85168682462 05/10/2023
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(Nishijima Y, Hader SN, Beyer AM.) Cardiovasc Res. 2023 Mar 17;119(1):e115-e117 PMID: 36708228 PMCID: PMC10236003 SCOPUS ID: 2-s2.0-85150665595 01/29/2023
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(Chabowski DS, Hughes WE, Hockenberry JC, LoGiudice J, Beyer AM, Gutterman DD.) J Physiol. 2023 Feb;601(3):469-481 PMID: 36575638 PMCID: PMC10979460 SCOPUS ID: 2-s2.0-85145823691 12/29/2022