Xiao-Mei Qi, MD

Associate Professor

Contact Information

General Interests

Cancer Biology and Cancer Research

Education

MD, Bengbu Medical College, 1982

Research Experience

Signal transduction in cancer

Educational Expertise

Supervise new postdoc and graduate students for their daily experiments

Research Interests

Faculty Collaboration Database

Cancer is a leading cause of human death and development of better therapeutics is a major task for cancer research. Nuclear receptors are a group of proteins that act as transcription factors to regulate gene expression in response to ligand treatment. Our major research interest is to explore novel functions of nuclear receptors in regulating therapeutic stress response by dissecting their signaling cross-talk with stress MAPKs.

Our studies have established that vitamin D receptor (VDR) is a stress responsive protein and its expression is induced by stress signaling through c-Jun/AP-1 pathways, which in turn inhibits stress-induced cell death. In human colon cancer cells, K-Ras mutation was shown to inactivate the VDR stress-regulatory pathway leading to an increased cell-death in response to stress p38 MAPK activation. In human breast cancer cells, on the other hand, our studies showed that estrogen receptor (ER) may inhibit stress-induced c-Jun-dependent cell death through a direct protein-protein interaction. These results together suggest that nuclear receptor VDR and ER may have dual biological roles: in response to ligand, they act as a receptor to mediate ligand-induced specific response through transcriptional regulations; in response to stress they function as a cell-death inhibitor through interacting and/or cross-talking with c-Jun-dependent pathways. Regulation of VDR/ER activity may consequently correspond to a novel strategy to increase cancer therapeutic response.

(Qin JZ, Xin H, Qi XM, Chen G.) Front Biosci (Landmark Ed). 2022 Jan 18;27(1):31 PMID: 35090336 SCOPUS ID: 2-s2.0-85124820704 01/30/2022
(Wang F, Qi XM, Wertz R, Mortensen M, Hagen C, Evans J, Sheinin Y, James M, Liu P, Tsai S, Thomas J, Mackinnon A, Dwinell M, Myers CR, Bartrons Bach R, Fu L, Chen G.) Cancer Res. 2020 Aug 15;80(16):3251-3264 PMID: 32580961 PMCID: PMC9358694 SCOPUS ID: 2-s2.0-85089787021 06/26/2020
(Qi XM, Wang F, Mortensen M, Wertz R, Chen G.) Acta Pharm Sin B. 2018 Jul;8(4):511-517 PMID: 30109176 PMCID: PMC6089844 SCOPUS ID: 2-s2.0-85048878016 08/16/2018
(Wu D, Zhao B, Qi X, Peng F, Fu H, Chi X, Miao QR, Shao S.) Cancer Lett. 2018 Apr 01;418:135-146 PMID: 29331415 PMCID: PMC7385903 01/15/2018
(Yin N, Qi X, Tsai S, Lu Y, Basir Z, Oshima K, Thomas JP, Myers CR, Stoner G, Chen G.) Oncogene. 2016 Feb 25;35(8):1039-48 PMID: 25961922 SCOPUS ID: 2-s2.0-84959509513 05/12/2015
(Qi X, Yin N, Ma S, Lepp A, Tang J, Jing W, Johnson B, Dwinell MB, Chitambar CR, Chen G.) Stem Cells. 2015 Sep;33(9):2738-47 PMID: 26077647 PMCID: PMC4792188 SCOPUS ID: 2-s2.0-84940467357 06/17/2015
(Ma S, Yin N, Qi X, Pfister SL, Zhang MJ, Ma R, Chen G.) Oncotarget. 2015 May 30;6(15):13320-33 PMID: 26079946 PMCID: PMC4537017 SCOPUS ID: 2-s2.0-84931073824 06/17/2015
(Qi X, Xie C, Hou S, Li G, Yin N, Dong L, Lepp A, Chesnik MA, Mirza SP, Szabo A, Tsai S, Basir Z, Wu S, Chen G.) Oncotarget. 2014 Jun 30;5(12):4269-82 PMID: 24962213 PMCID: PMC4147322 SCOPUS ID: 2-s2.0-84905098265 06/26/2014
(Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G.) J Biol Chem. 2012 Aug 10;287(33):27895-905 PMID: 22730326 PMCID: PMC3431700 SCOPUS ID: 2-s2.0-84865009345 06/26/2012
(Kobayashi Y, Qi X, Chen G.) Genes Cancer. 2012 Jul;3(7-8):521-30 PMID: 23264852 PMCID: PMC3527985 12/25/2012
(Qi X, Zhi H, Lepp A, Wang P, Huang J, Basir Z, Chitambar CR, Myers CR, Chen G.) J Biol Chem. 2012 Apr 27;287(18):14681-91 PMID: 22399296 PMCID: PMC3340246 SCOPUS ID: 2-s2.0-84860370781 03/09/2012
(Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G.) Cancer Res. 2010 Apr 01;70(7):2901-10 PMID: 20332238 PMCID: PMC2848905 SCOPUS ID: 2-s2.0-77950794747 03/25/2010

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