Joseph Hennessey
Phase 1 Second Year Student
Locations
- Medical Scientist Training Program
Contact Information
Education
Research Interests
Applying the tools of systems neuroscience, neurobiology, and pharmacology to gain insights into mechanisms of neural plasticity and the mechanisms by which novel plasticity-inducing therapeutics can be used to treat stress-linked psychiatric diseases.
Research Experience
91ɫƵ, 2022-2023
Advisor: John McCorvy
Project: Characterization of biased agonism of psychedelics at aminergic GPCRs
Marquette University, 2021-2022
Advisor: Alex Savtchouk, PhD
Project: Anatomical tracing of cerebello-thalamo-cortical circuitry
Marquette University, 2019-2020
Advisor: John Mantsch, PhD
Project: Neuropsychopharmacology of stress contributions to cocaine seeking
Publications
Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD. Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential. Nat Commun. 2023 Dec 15;14(1):8221. doi: 10.1038/s41467-023-44016-1. PMID: 38102107; PMCID: PMC10724237.
Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, Cameron LP, Patel SD, Hennessey JJ, Saeger HN, McCorvy JD, Gray JA, Tian L, Olson DE. Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science. 2023 Feb 17;379(6633):700-706. doi: 10.1126/science.adf0435. Epub 2023 Feb 16. PMID: 36795823; PMCID: PMC10108900.
General Interests
Brazilian jiu-jitsu, meditation, environmentalism, hiking, soccer, philosophy, and cooking