Precision Oncology & Cancer Genomics | Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Precision Oncology & Cancer Genomics Program

Hundreds of genes influence the development, treatment, and outcomes of patients with various cancers. Mellowes Center researchers investigate the genetic, epigenetic (changes caused by the activation or deactivation of genes), and environmental factors that lead to cancer. These studies show the most promise for personalizing cancer care and establishing novel workflows that improve the prevention, diagnosis, and treatment of cancer based on each patient鈥檚 genetic makeup.

Through its partnership with the 91九色视频 Cancer Center, Mellowes Center Precision Oncology faculty harness this power of precision medicine to accelerate innovative research via tumor boards, the , and the new , which will accelerate novel studies and develop personalized treatments for rare cancers.

Program Faculty

Hui-Zi Chen, MD, PhD

Assistant Professor

Victor X. Jin, PhD

Linda T. and John A. Mellowes Endowed Chair of Bioinformatics and Data Analytics; Professor, IHE/Biostatistics

vjin@mcw.edu

Razelle Kurzrock, MD, FACP

Center Associate Director, Professor

Gwen Lomberk, PhD

Chief, Division of Research; Director, Basic Science Research; Department of Surgery; Professor of Surgery and Pharmacology & Toxicology

glomberk@mcw.edu

Raul A. Urrutia, MD

Professor, Department of Surgery; Director, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Michael T. Zimmermann, PhD

Director, Computational Structural Genomics Unit, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Precision Oncology & Cancer Genomics Sample Publications

. Shaya J, Kato S, Adashek JJ, Patel H, Fanta PT, Botta GP, Sicklick JK, Kurzrock R npj Genomic Medicine December 2023;8(1) SCOPUS ID: 2-s2.0-85146753220

. Pollin G, De Assuncao TM, Doria Jorge S, Chi YI, Charlesworth MC, Madden B, Iovanna JL, Zimmermann MT, Urrutia R, Lomberk G. Biosci Rep. 2023 Oct 2:BSR20231093. doi: 10.1042/BSR20231093. Online ahead of print.PMID: 37782747

. Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R. Genome Biol (IF: 10.81; Q1). 2021 Oct 14;22(1):289. doi: 10.1186/s13059-021-02498-6.PMID: 34649604

. Fraunhoffer NA, Moreno Vega AI, Abuelafia AM, Morvan M, Lebarbier E, Mary-Huard T, Zimmermann MT, Lomberk G, Urrutia R, Dusetti N, Blum Y, Nicolle R, Iovanna J.E BioMedicine. 2023 Jun;92:104602. doi: 10.1016/j.ebiom.2023.104602. Epub 2023 May 4.PMID: 37148583

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