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Research Bench Lab
Microbiology & Immunology

Lochhead Laboratory

Location
Microbiology & Immunology
BSB B2750

General Interests
Lyme Disease, Inflammation, Autoimmunity

View Robert Lochhead Bio
Robert Lochhead Laboratory
Overview of LD

Research Areas

The Lochhead Lab focuses on mechanisms of arthritis pathogenesis, using animal models of Lyme arthritis and clinical samples collected from patients with various types of arthritis. Much of our research focuses on Lyme disease, caused by infection with the tick-borne pathogen Borrelia burgdorferi (Bb). Lyme disease is the most common vector-borne disease in the U.S., and is reaching epidemic levels in many regions, including the Upper Midwest. Lyme disease is an infection-induced multi-system disorder affecting skin (erythema migrans), heart (carditis), joints (arthritis) or neurologic tissue (neuro-borreliosis). Lyme arthritis (LA) is the most common late-stage manifestation of Lyme disease. Although most patients are effectively treated with antibiotics, 10-20% of treated patients develop post-infectious Lyme arthritis, potentially resulting in months or years of disability. Identifying immune factors that contribute to variability in disease severity and treatment outcome is critically important for public health in Lyme-endemic communities such as Wisconsin. By studying LA, we hope to gain important insights into how infection may trigger immune dysregulation, leading to tissue damage, arthritis, and autoimmunity,

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Current Members

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Lauren Hackner

Research Technologist, Lochhead Lab

lhackner@mcw.edu

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Lauren Prochniak

Graduate Student

lprochniak@mcw.edu

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Joseph Rouse

Graduate Student

jorouse@mcw.edu

Recent Publications

  • (Rouse JR, Danner R, Wahhab A, Pereckas M, Nguyen C, McClune ME, Steere AC, Strle K, Jutras BL, Lochhead RB.) ACR Open Rheumatol. 2024 Oct;6(10):678-689 PMID: 39073021 PMCID: PMC11471949 SCOPUS ID: 2-s2.0-85200034334 07/29/2024

  • (Danner R, Prochniak LM, Pereckas M, Rouse JR, Wahhab A, Hackner LG, Lochhead RB.) J Infect Dis. 2024 Aug 14;230(Supplement_1):S27-S39 PMID: 39140726 PMCID: PMC11322890 SCOPUS ID: 2-s2.0-85201242786 08/14/2024

  • (Holub MN, Wahhab A, Rouse JR, Danner R, Hackner LG, Duris CB, McClune ME, Dressler JM, Strle K, Jutras BL, Edelstein AI, Lochhead RB.) Arthritis Res Ther. 2024 Mar 27;26(1):77 PMID: 38532447 PMCID: PMC10967045 SCOPUS ID: 2-s2.0-85188752768 03/27/2024

  • (Holub MN, Wahhab A, Rouse JR, Danner R, Hackner LG, Duris CB, McClune ME, Dressler JM, Strle K, Jutras BL, Edelstein AI, Lochhead RB.) Arthritis Research and Therapy. December 2024;26(1) SCOPUS ID: 2-s2.0-85188752768 12/01/2024

  • (Danner R, Pereckas M, Prochniak L, Rouse JR, Wahhab A, Hackner LG, Lochhead RB. .) Journal of Infection Diseases (revised manuscript under review). 05/29/2024

  • (Rouse JR, Danner R, Wahhab A, Pereckas M, McClune ME, Steere AC, Strle K, Jutras BL, Lochhead RB.) bioRxiv. 2023 Nov 29 PMID: 38045407 PMCID: PMC10690166 12/04/2023

  • (Kanjana K, Strle K, Lochhead RB, Pianta A, Mateyka LM, Wang Q, Arvikar SL, Kling DE, Deangelo CA, Curham L, Barbour AG, Costello CE, Moon JJ, Steere AC.) J Clin Invest. 2023 Sep 01;133(17) PMID: 37471146 PMCID: PMC10471169 SCOPUS ID: 2-s2.0-85169502176 07/20/2023

  • (Ordóñez D, Lochhead RB, Strle K, Pianta A, Arvikar S, Van Rhijn I, Stemmer-Rachamimov A, Steere AC.) Arthritis Rheumatol. 2023 May;75(5):782-793 PMID: 36413215 PMCID: PMC10191881 SCOPUS ID: 2-s2.0-85150932196 11/23/2022

  • (Rebecca Danner, Michael Perekas, Joseph Rouse, Amanda Wahhab, and Robert Lochhead.) Journal of Proteome Research (in prep). 03/29/2023

  • (Meaghan Holub, Amanda Wahhab, Joseph Rouse, Rebecca Danner, Mecaila McClune, Jules Dressler, Brandon Jutras, Adam Edelstein, and Robert Lochhead.) Arthritis and Rheumatology (in prep). 03/29/2023

  • (Joseph Rouse, Amanda Wahhab, Rebecca Danner, and Robert Lochhead.) Journal of Experimental Medicine (in prep). 03/29/2023

Publications of from the

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