Spearman Lab

Research in the Spearman Lab is focused on understanding the mechanisms of vascular remodeling in congenital heart disease. We are currently investigating the pathophysiology of pulmonary vascular remodeling in single ventricle congenital heart disease 鈥� specifically pulmonary arteriovenous malformations and aortopulmonary collaterals.

Recruiting for Research Technologist I

Join the Spearman Lab to provide support for pediatric cardiology research through projects, maintenance and communication of data, and execution of laboratory experiments.

Lab Research

Patients with palliated single ventricle congenital heart disease have greatly improved survival today due to multiple medical and surgical innovations. Improved survival has also led to increased prevalence of unintended complications of palliated single ventricle circulation. One widely recognized complication is the development of pulmonary arteriovenous malformations (PAVMs). Our current research utilizes patient tissue samples, surgical animal models, and in vitro approaches to study PAVMs.

Our research seeks to answer key questions about single ventricle PAVMS:

What is the pathologic progression of pulmonary vascular remodeling in single ventricle PAMVs?
How do hepatic vein blood and blood flow regulate normal pulmonary vascular homeostasis?
What are the critical factors in hepatic vein blood that prevent PAVMs? In other words, what is hepatic factor?
How do single ventricle PAVMs compare to heritable forms of PAVMs?

Recent Publication

Glenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations

Lab Updates

Dr. Andrew Spearman wins 2024 Young Hearts Early Career Investigator Award from the American Heart Association

Dr. Andrew Spearman wins 2024 Single Ventricle Research Fund Award for "Longitudinal analysis of single ventricle PAVM pathophysiology"

Meet Our Team

Andrew D. Spearman, MD

Associate Professor

Tina Wan, PhD

Research Scientist

Henry Rousseau, BA

Research Technician

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