91ɫƵ Translational Cores
91ɫƵ translational resources provide clinical grade services adapted to investigator protocols for research involving adult and pediatric participants and model systems. Translational research is supported across a range of disciplines that include cardiology, oncology, neuroscience and disease outcome.
List of Translational Cores
Part of the Data Science Institute, the Biostatistics Consulting Service provides comprehensive statistical consulting. Services cover the spectrum of cancer-related and non-cancer research including: experimental design, sample size calculation, randomization, data analysis, design and analysis of clinical trials, observational studies and surveys, assistance with public databases and innovative methods development.
Co-Directors: Aniko Szabo, PhD and Paul Auer, PhD
The Cardiovascular Academic Initiative is an organized clinical and translational initiative to focus and support the cardiovascular academic missions and intertwine them with the clinical missions of 91ɫƵ.
Cell Therapy Laboratory (CTSR)
The Cell Therapy Shared Resource provides advanced technologies and expertise to develop innovative and effective cell therapies. We offer 1) state-of-the-art production and processing of cell therapy products including on-site CAR-T cell manufacturing, and 2) access to cutting-edge instrumentation for immune profiling (Berkeley Lights Optofluidics, Droplet digital PCR, Isoplexis, Luminex) and immune-oncology consulting services.
Co-Directors: Tyce Kearl, MD, PhD and Peiman Hematti, MD
The Center for Imaging Research provides high-field MRI for functional MRI, structural imaging, dynamic contrast imaging, and diffusion imaging. Animal preparation including survival surgery and post-imaging support can be performed in our facility.
Director: Andrew Nencka, PhD
Echocardiography is the cornerstone of the phenotyping process. Its highly versatile nature makes it the non-invasive tool of choice. This form of non-invasive assessment is ideal for performing serial evaluations of cardiac function or real-time monitoring during and after pharmacological or therapeutic intervention.
Co-Directors: Divyanshu Mahonaney, MD and Noelle Garster, MD; Research Sonographer: Lindsey Kalvin, ACS, BS, RDCS (AE & PE), FASE
The Echo Core – Shared High Frequency Ultrasound Imaging Facility has a self-use FUJIFilm VisualSonics Vevo 3100 preclinical high frequency/resolution imaging system for preclinical in vivo imaging for oncology, cardiovascular, neurobiology, developmental and other conditions. Transducers: MX250, MX550D, MX700 are available for image-guided injections, color doppler, contrast imaging & 4D. Isoflurane sedation, warming platforms & VevoLAB data analysis software are available, including strain analyses.
Director: John Auchampach, PhD; Manager: Tina Wan, PhD
The Geospatial, Epidemiology, and Outcomes Shared Resource (GEOSR) provides access for cancer and non-cancer studies to population-based data, cancer epidemiology and database expertise, cancer burden in the catchment area, and geospatial mapping and analysis to catalyze population-based cancer research. The GEOSR also assists non-cancer and cancer-focused investigators with accessing and utilizing electronic health record (EHR) data, including -omics data, and matching patients to clinical trials.
Co-Directors: Kirsten Beyer, PhD, MPH, MS, Anai Kothari, MD, MS and Tina Yen, MD, MS, FACS, FSSO
The Department of Radiology, in collaboration with the 91ɫƵ’s Clinical Cancer Center (91ɫƵCC) Clinical Trials Office, supports the assessment of tumor response to therapy guided by board certified radiologists. The QIL support clinical trials using Precision Imaging Metrics software to track and maintain clinical trial response criteria.
Co-Directors: Peter LaViolette, PhD and Stephanie Vincent-Sheldon, MD; Quality Analysts: Maureen Levenhagen and Allie Lowman